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Why Aivlosin® is so Effective
2 - It gets to the site of infection
3 - Advantages to non-specific immunity
4 - Targets bacteria both inside and outside cells
5 - Aivlosin® at labelled concentrations is bactericidal for Mycoplasma
8 - It has a high safety margin
9 - It has no known incompatibilities
Aivlosin® is rapidly absorbed, achieving peak blood levels within 2 hours. It achieves rapid tissue uptake, especially into lungs.
It has far higher absorption than a competitor molecule used at the same dose rate. The area under the curve (AUC) is 3 times greater.
Aivlosin® in Pigs
Pigs given antibiotic at 50mg/kg bodyweight. Area Under Curve(AUC)is 60.1µg.hr/ml for Aivlosin and 6.23µg.hr/ml for the competitor
Aivlosin® in Poultry
Chickens given antibiotic at 50mg/kg bodyweight. Area Under Curve (AUC) is 20.1µg.hr/ml for Aivlosin and 6.23µg.hr/ml for the competitor
2 - It gets to the site of infection
Aivlosin® concentrates within phagocytic cells, which are then attracted by chemical signals to the site of infection.
Once there, the phagocytic cells can engulf the pathogen. The presence of high concentrations of antibiotic inside the cell can kill the pathogen directly.
Aivlosin® is very effective against both respiratory and enteric pathogens, and accumulates in target tissues.
- It is known to have several-fold higher concentrations in the lung than in plasma, including in the mucous lining of the airways. This is important as a primary means of combating respiratory pathogens at their initial site of entry.
- It is also highly concentrated in bile, so is present in the alimentary tract in high concentrations against enteric pathogens.
3 - Advantages to non-specific immunity
Phagocytic cells, principally macrophages and neutrophils, take up Aivlosin® making the intracellular concentration very high compared to the extracellular concentration of the active molecule.
Aivlosin® can also affect macrophages:
- Macrophages become more active
- Increased monocyte to macrophage differentiation.
4 - Targets bacteria both inside and outside cells
Aivlosin® is rapidly taken into phagocytic cells, resulting in high intracellular concentrations. Phagocytic cells move rapidly to the site of infection. The high intracellular concentrations of Aivlosin® can have a direct effect on killing susceptible pathogens that are engulfed by the cell.
In addition, if the extracellular concentration of Aivlosin® is low relative to the intracellular concentration, Aivlosin is released from phagocytic cells into the microenvironment. Therefore, the antibiotic can have an effect on pathogens extracellularly as well as intracellularly.
5 - Aivlosin® at the recommended dose rates can be bactericidal for Mycoplasma
The minimum bactericidal concentration (MBC) for Aivlosin® is similar to the minimum inhibitory concentration (MIC). The bactericidal (killing) effect of the antibiotic helps the immune system to overcome the infection. The killing activity of Aivlosin® is both concentration- and time-dependent.
6 - It has more than one site of action
Aivlosin® binds to the bacterial ribosome and prevents protein synthesis. This can lead to inhibition of bacterial growth or death of the bacteria. Aivlosin®'s first metabolite, known as 3-AT, also has antimicrobial activity. It attaches to a different site on the ribosome and so enhances the effectiveness of Aivlosin®.
The palatability of Aivlosin® medicated products encourages the uptake of the medicated feed, and combined with its rapid disease resolution, helps to achieve optimal growth.
8 - It has a high safety margin
Large overdoses of the antibiotic have been given to pigs and poultry without the occurrence of any side effects.
There are no known contra-indications with the use of Aivlosin® in pigs and poultry.
Phase I and Phase IIA environmental risk assessments have been undertaken in accordance with CVMP guidelines showing Aivlosin® is of low risk to the environment.
9 - It has no known incompatibilities
There are no known incompatibilities with other veterinary products. Aivlosin® may be used with other medicines (including ionophores), vitamins and minerals.
